Northwestern University Feinberg School of Medicine

Parkinson's Disease and Movement Disorders Center

Safety and Efficacy Study of Tozadenant to Treat End of Dose Wearing Off in Parkinson's Patient's Using Levodopa (TOZ-PD)

Study Title:  Safety and Efficacy Study of Tozadenant to Treat End of Dose Wearing Off in Parkinson's Patient's Using Levodopa (TOZ-PD)

ClinicalTrails.gove Identified:  NCT02453386

Clinical Trial Investigator:  Cindy Zadikoff, MD

The purpose of this study is to test the effect of tozadenant tablets compared to a placebo.  To evaluate the drug, you will be asked to carefully maintain an accurate record of your ON and OFF time in a home diary.  Other symptoms that some patients with PD experience will be evaluated during clinic visits.  This study will also lok at whether or not tozadenant decreases end of dose wearing off in PD patients and will show wha side-effects can be expected and how troublesome they may be.  This portion of the study is "double-blind", which means that neither you nor y our study doctor/study team can choose or will know to which dose group y ou have been assigned (tozadenant or placebo).  In the open-label phase, subjects previously given placebo will be allowed to receive tozadenant treatment.  

Clinical Trial Eligibility Criteria:

Study Visits: 15 visits over 81 weeks

Treatment:  APL-130277 (sublingual apomorphine thin films) or Placebo

Compensation: $50 for each study visit

IRB#: Project: STU00201468

For More Information: Call us at 312-503-0755, or email pdclinicaltrials@northwestern.edu.